phenyTOIN mg IV Q8H mg PO daily When to PO give total IV daily dose once daily Oral bioavailability greater than 90% 1,2 methylPREDNISolone sodium variable predniSONE variable dose PO daily Convert to predniSONE File Size: KB. For this reason, plasma phenytoin concentrations may increase modestly when IV phenytoin is substituted for oral phenytoin sodium therapy. The rate of administration for IV phenytoin should be no greater than 50 mg per minute in adults and mg/kg/min (or 50 mg per minute, whichever is slower) in pediatric patients. Phenytoin and now fosphenytoin are probably the most frequently used anticonvulsants for SE. The older formulation (phenytoin in a basic solution ethylene glycol) is still used because its cost is substantially lower. However, intravenous phenytoin has three major disadvantages: A longer time is required to achieve therapeutic levels. Procedure for Administration of Phenytoin as IV Infusion. A. For doses of more than mg and/or infusion rates of 50 mg/min (pediatric: 1mg/kg/min) the patient should be on a cardiac monitor with rate, rhythm, and blood pressure display. B. Hang IV solution of normal saline (use if IV solution other than normal saline. Phenytoin, supplied as Cerebyx, is % bioavailable by both the IM and IV routes. For this reason, plasma phenytoin concentrations may increase modestly when IM or IV Cerebyx is substituted for oral phenytoin sodium therapy. The rate of administration for IV . Phenytoin oral doses may be advantageous in stable patients with subtherapeutic phenytoin concentrations, particularly in those to the emergency department without IV Because phenytoin has demonstrated some saturable and erratic oral absorption beyond mg, the use of large oral doses is controversial. mg/kg PO/NG- given as mg qh. mg/kg/day in one daily dose If > mg/day - two doses. mg/kg/day in 2 to 3 doses. may need times IV/PO dose; hold feeds 2 hrs before and after a daily dose; Flush tube well with 50mL sterile water. Phenytoin capsules are available in the strengths- 25mg, 50mg, mg Correction of phenytoin levels in hypoalbuminaemia and renal failure Phenytoin is highly protein bound and where protein is reduced, as in uraemia and hypoalbuminaemia, free phenytoin concentration levels will be increased. Start common IV -> PO conversions & some Learn vocabulary, terms, and more with flashcards, games, and other study tools. Intravenous (IV) to Enteral (PO) Conversion of Medications Hospital Policy. PURPOSE. The purpose of this policy is to implement a program that enables our hospital pharmacists to convert IV medications to the enteral (PO or via tube) route of administration when appropriate.
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Phenytoin (Dilantin) Correction Calculator - lbjnq.linkpc.net
For this reason, plasma phenytoin concentrations may increase modestly when IV phenytoin is substituted for oral phenytoin sodium therapy. The rate of administration for IV phenytoin should be no greater than 50 mg per minute in adults and mg/kg/min (or 50 mg per minute, whichever is slower) in pediatric patients. Conversion to once daily Consider only after a divided dose regimen on extended phenytoin capsules is established. (Only extended release Dilantin caps are recommended for once daily administration.) A patient should never receive a once daily dose of elixir or injection as maintenance. When do you start the maintenance dose? 1. Allen JP, Ludden TM, Burrow SR, Clementi WA, Stavchansky SA. Phenytoin cumulation kinetics. Clin Pharmacol Ther. Oct;26(4) 2. Bachmann KA, Belloto RJ.