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Phenytoin to fosphenytoin conversion

Overview
Apr 15,  · Such is the case with phenytoin equivalents. Fosphenytoin is a water-soluble prodrug of phenytoin. After IV administration, much of the fosphenytoin is metabolized to phenytoin within 15 minutes. Advantages over phenytoin include the option for IM administration and less cardiotoxicity for faster infusion rates. Fosphenytoin is dosed in phenytoin equivalents (or PEs). All you have to remember about this is that fosphenytoin 1mg PE = phenytoin 1mg. So let's say you're with status epilepticus, and your reference states that the dose of phenytoin for status epilepticus is phenytoin 20mg/kg. The Phenytoin (Dilantin) Correction for Albumin / Renal Failure corrects serum phenytoin level for renal failure and/or hypoalbuminemia. This is an unprecedented time. It is the dedication of healthcare workers that will lead us through this. Phenytoin/Fosphenytoin Administration Guidelines Purpose: The purpose of this issuance is to establish safe guidelines for administration of IV phenytoin and fosphenytoin either intravenous push or intravenous infusion. Guidance: Intravenous phenytoin or phosphenytoin will be administered by the administration routes, at the. The dose, concentration in solutions, and infusion rate of IV Cerebyx is expressed as phenytoin sodium equivalents (PE) to avoid the need to perform molecular weight-based adjustments when between fosphenytoin and phenytoin sodium doses. Cerebyx should always be prescribed and dispensed in phenytoin sodium equivalent units (PE). IM or IV Substitution for Oral Phenytoin Therapy Fosphenytoin sodium injection can be substituted for oral phenytoin sodium therapy at the same total daily dose. Phenytoin sodium capsules are approximately 90% bioavailable by the oral route. Phenytoin, supplied as fosphenytoin sodium injection, is % bioavailable by both the IM and IV routes. Fosphenytoin is dosed in phenytoin equivalents (PE) 1 PE fosphenytoin = 1 mg phenytoin sodium = mg fosphenytoin sodium 2. Total body weight (TBW) is defined as the actual total mass of the patient in kilogramsFile Size: 1MB. Phenytoin and now fosphenytoin are probably the most frequently used anticonvulsants for SE. The older formulation (phenytoin in a basic solution ethylene glycol) is still used because its cost is substantially lower. However, intravenous phenytoin has three major disadvantages: A longer time is required to achieve therapeutic levels. Nov 10,  · Because its molecular weight is different than that of phenytoin, one milligram of fosphenytoin does not equal one milligram of phenytoin. To avoid confusion, fosphenytoin doses are reported as "mgPE" (milligrams of phenytoin equivalents). mgPE, no adjustment is needed when between phenytoin and fosphenytoin.

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Understanding Phenytoin Equivalents

Fosphenytoin is dosed in phenytoin equivalents (PE) 1 PE fosphenytoin = 1 mg phenytoin sodium = mg fosphenytoin sodium 2. Total body weight (TBW) is defined as the actual total mass of the patient in kilogramsFile Size: 1MB. The dose, concentration in solutions, and infusion rate of IV Cerebyx is expressed as phenytoin sodium equivalents (PE) to avoid the need to perform molecular weight-based adjustments when between fosphenytoin and phenytoin sodium doses. Cerebyx should always be prescribed and dispensed in phenytoin sodium equivalent units (PE). Apr 15,  · Such is the case with phenytoin equivalents. Fosphenytoin is a water-soluble prodrug of phenytoin. After IV administration, much of the fosphenytoin is metabolized to phenytoin within 15 minutes. Advantages over phenytoin include the option for IM administration and less cardiotoxicity for faster infusion rates.

 

Fosphenytoin - FDA prescribing information, side effects and uses

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